Centers
Co-Directors: Bhanu P. Jena [MMI] & Douglas J. Taatjes [UVM]
Participating Institutions & Investigators: Ionita Ghiran [Harvard Medical School]; Walter F. Boron [Case Western]; Yongxin Zhao [Carnegie Mellon University]; Won Jin Cho [MMI].
Repurposing naturally available small molecules to reversibly modulate biomembrane transport functions
The mission of CBC is to establish fundamental new approaches to reversibly program the chemistry of biological membranes to selectively prevent the entry of toxins and pathogens into the cellular environment, while enabling normal membrane transport functions in cells. This will transform our molecular level understanding of biological membranes and enable the development of novel technologies and the design and use of naturally occurring small biomolecules to regulate membrane functions in a sustainable manner, to benefit science and society. To achieve this, we have assembled a multidisciplinary collaborative team to leverage our understanding of the chemistry of lipids and proteins in biological membranes, to modulate their chemistry with great precision.
METABOLISM-SKELETAL MUSCLE-DIABETES
Center for Diabetes
Center for Muscle Biology
INFECTIOUS DISEASES
Immunology and Virology Research Center
DIAGNOSTIC AND MOLECULAR PATHOLOGY
Center for Pathology Innovations and Biobank
Center for Molecular Imaging
Center for Machine Learning and AI